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(2000) Ef cient lipid-mediated gene transfer to articular chondrocytes Gene Ther 7(4): 286 291 Madry, H, Zurakowski, D, Trippel, SB (2001) Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation Gene Ther 8(19): 1443 1449 Neves, C, Escriou, V, Byk, G, Scherman, D, Wils, P (1999) Intracellular fate and nuclear targeting of plasmid DNA Cell Biol Toxicol 15(3): 193 202 Pallante, KM, Niu, Z, Zhao, Y, Cohen, AJ, Nah, HD, Adams, SL (1996) The chick alpha2(I) collagen gene contains two functional promoters, and its expression in chondrocytes is regulated at both transcriptional and post-transcriptional levels J Biol Chem 271(41): 25233 25239 Ravid, K, and Freshney, RI (1998) DNA Transfer to Cultured Cells Wiley-Liss, New York Sa nya, CR.

(2001) Structures of lipid-DNA complexes: supramolecular assembly and gene delivery Curr Opin Struct Biol 11(4): 440 448 Sambrook, J, Fritsch, EF, Maniatis, T (1989) In: Maniatis, T, ed, Molecular Cloning: A Laboratory Manual Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press San, H, Yang, ZY, Pompili, VJ, Jaffe, ML, Plautz, GE, Xu, L, Felgner, JH, Wheeler, CJ, Felgner, PL, Gao, X, et al (1993) Safety and short-term toxicity of a novel cationic lipid formulation for human gene therapy Hum Gene Ther 4(6): 781 788 Seisenberger, G, Ried, MU, Endress, T, Buning, H, Hallek, M, Brauchle, C (2001) Realtime single-molecule imaging of the infection pathway of an adeno-associated virus Science 294(5548): 1929 1932 Smith, P, Shuler, FD, Georgescu, H.

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I, Ghivizzani, SC, Johnstone, B, Niyibizi, C, Robbins, PD, Evans, CH (2000) Genetic enhancement of matrix synthesis by articular chondrocytes J Rheumatol 43(5): 1156 1164 Vunjak-Novakovic, G, Martin, I, Obradovic, B, Treppo, S, Grodzinsky, AJ, Langer, R, Freed, LE (1999) Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage J Orthop Res 17(1): 130 138 Vunjak-Novakovic, G, Obradovic, B, Martin, I, Bursac, PM, Langer, R, Freed, LE (1998) Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering Biotechnol Prog 14(2): 193 202 Zhou, F, and Huang, L (1994) Liposome-mediated cytoplasmic delivery of proteins: an effective means of accessing the MHC class I-restricted antigen presentation pathway Immunomethods 4(3): 229 235 Zhou, X, and Huang, L.

(1994) DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action Biochim Biophys Acta 1189: 195 203..

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Unitarily equivalent matrices: The (m x 11) matrices A and Bart' unitarily f'quivaient if there exists a unitary (m x m) matrix C and a uuitary (/I x 11) matrix ~', such that A = f.!H B~ . (See also Section 9.15.) Unitarily similar matrices: The (m x In) matrices A and B are unitarily similar if a unitary (m x It!) matrix U exists such that B = U A[: H (Sf'e also Section 9.15.) Unitary matrix: An (m x m) matrix A IS unitary if AH Section 9 15 for t he properties.) A-I. (SeC'

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Diet a1 No treadmill exercise (b1) Treadmill exercise (b2) Y 11 = 7.0 S 11 = 4.0 Y 12 = 9.0 S 12 = 3.4 Y 1 = 8.0 S 1 = 3.8

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